Preferential Crystallization of 2-Amino-2-phenylethanol and Its Application as a Resolving Agent
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Optical Resolution by Preferential Crystallization of (RS)-2-Amino-3-(2-carboxyethylthio)propanoic Acid.
Electrophilic additions of DL- and L-Cys to propenoic acid afforded (RS)- and (R)-2-amino-3-(2-carboxyethylthio)propanoic acids [(RS)- and (R)-ACE], respectively. (RS)-ACE was found to exist as a conglomerate based on its melting point, solubility, and infrared spectrum. (RS)-ACE was optically resolved by preferential crystallization to yield (R)- and (S)-ACE. The obtained (R)- and (S)-ACE were...
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To synthesize optically active 2-amino-2-methyl-3-phenylpropanoic acid (1), (RS)-2-benzoylamino-2-benzyl-3-hydroxypropanoic acid [(RS)-2] was first optically resolved using cinchonidine as a resolving agent to yield optically pure (S)- and (R)-2 in yields of about 70%, based on half of the starting amount of (RS)-2. Next, the racemic structure of (RS)-2 was examined based on melting point, solu...
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an improved synthesis and preliminary biodistribution study of a technetium-99m-labeled 2-amino-2-deoxy(thioacetyl)-d-glucose complex ([99mtc]-ta-dg) as a tumor imaging agent
introduction: this report describes the synthesis of 2-amino-2-deoxy(s-benzoylthioacetyl)-d-glucose (s-bz-ta-dg), radiolabeled with [99mtc(co)3(oh2)3]+ complex with a procedure including deprotection of the benzoyl group, characterization by hplc using a c18 reverse phase column and preliminary biodistribution study in normal mice. methods: [99mtc(co)3(h2o)3]+ complex was used to label ta-dg w...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1982
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.55.1188